Abstract Background Physical activity (PA) prescription has the potential to be an important therapeutic agent for all ages in primary, secondary and tertiary prevention of chronic disease (Thornton et al., 2016). However, physicians report that they do not deliver PA counselling because of limitations in time, knowledge, confidence, and practical tools (Meriwether, Lee, Lafleur, & Wiseman, 2008). Physical educators have the required skills to address those issues in encouraging patients to adopt an active lifestyle that will reduce the incidence of their chronic conditions. In Belgium, physical activity prescription initiatives are emerging: this study aimed at monitoring one of these to ensure the development of evidence-based intervention relying on HEPA best practices. Methods With a PA prescription from their doctor, patients with chronic cardiac, neurological, metabolic, oncologic or spinal disease took part to a 6-month intervention supervised by physical educators in a Belgian municipality. The program was composed of weekly sessions of physical exercise focusing on the 4 dimensions of physical fitness according to international recommendations (ACSM, 2016). Monthly motivational sessions were also organized to promote active lifestyle. Monthly assessments included PA level (Ricci & Gagnon,2011), SF-36 (Ware & Sherbourne, 1992), and Senior Fitness Test (Rikli & Jones, 2001). Results Preliminary results after one month intervention on 19 patients (68.6 ± 10.8 years) with chronic cardiac (n = 11), neurological (n = 2), metabolic (n = 1), oncological (n = 4) or spinal (n = 1) disease exposed significant improvements of their lower (p = 0.03) and upper (p = 0.01) body strength, and aerobic endurance (p = 0.17). No significant changes were observed for physical activity level and SF-36 scores. Further results will provide information about the impact of motivational sessions on the adoption of an active lifestyle. Conclusions Physical activity prescription supervised by physical educators has ...