Rapid Whole Genome Sequencing Diagnoses and Guides Treatment in Critically Ill Children in Belgium in Less than 40 Hours.
peer reviewed ; Rapid Whole Genome Sequencing (rWGS) represents a valuable exploration in critically ill pediatric patients. Early diagnosis allows care to be adjusted. We evaluated the feasibility, turnaround time (TAT), yield, and utility of rWGS in Belgium. Twenty-one unrelated critically ill patients were recruited from the neonatal intensive care units, the pediatric intensive care unit, and the neuropediatric unit, and offered rWGS as a first tier test. Libraries were prepared in the laboratory of human genetics of the University of Liège using Illumina DNA PCR-free protocol. Sequencing... Mehr ...
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Dokumenttyp: | journal article |
Erscheinungsdatum: | 2023 |
Verlag/Hrsg.: |
MDPI AG
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Schlagwörter: | Base Space Sequence Hub / Dragen / NICU / NICU-Seq / critically ill newborn / rWGS / rapid whole genome sequencing / Inorganic Chemistry / Organic Chemistry / Physical and Theoretical Chemistry / Computer Science Applications / Spectroscopy / Molecular Biology / General Medicine / Catalysis / Human health sciences / Sciences de la santé humaine |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-26593247 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://orbi.uliege.be/handle/2268/301232 |