Vitamin K requirement of two VKORC1 resistant Norway rat (Rattus Norvegicus) strains common in Belgium:Y139F and L120Q

Vitamin K is an essential co-factor in the activation of several coagulation factors and plays an important role in blood coagulation. Resistance against anticoagulant rodenticides is based on a single nucleotide polymorphism in the VKORC1 gene. A pleiotropic effect of rodenticide resistance is an increased need for vitamin K. Therefore we tested homozygous resistant rats (Y139F, L120Q) for their vitamin K requirement by feeding six males and six females of each strain with a vitamin K deficient diet (Altromin) for two weeks, yet coprophagy was not prevented. Then on day 0,3,5,7,10,14 of the e... Mehr ...

Volltext
Verfasser: Baert, Kristof
Stuyck, Jan
Dokumenttyp: contributionToPeriodical
Erscheinungsdatum: 2013
Schlagwörter: /dk/atira/pure/thematic/inbo_th_00146 / Rat extermination / /dk/atira/pure/discipline/B000/B007/B470-fysiologie / B470-physiology / /dk/atira/pure/discipline/B000/B005/B360-dierenfysiologie / B360-animal-physiology / /dk/atira/pure/taxonomic/knaagdieren_rodentia_ / rodents (Rodentia) / /dk/atira/pure/policy/faunabeheer / fauna management / /dk/atira/pure/geographic/belgi_ / Belgium / /dk/atira/pure/technological/biotechnologie / biotechnology / rodenticide resistance
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-26591073
Datenquelle: BASE; Originalkatalog
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Link(s) : https://data.inbo.be/pureportal/en/publications/vitamin-k-requirement-of-two-vkorc1-resistant-norway-rat-rattus-norvegicus-strains-common-in-belgium(efd7cca1-68ec-44f5-ba81-c32845300f77).html