Adverse drug reactions to tocolytic treatment for preterm labour: prospective cohort study

ABSTRACT Objective To evaluate the incidence of serious maternal complications after the use of various tocolytic drugs for the treatment of preterm labour in routine clinical situations. DESIGN Prospective cohort study. SETTING 28 hospitals in the Netherlands and Belgium. PARTICIPANTS 1920 consecutive women treated with tocolytics for threatened preterm labour. MAIN OUTCOME MEASURES Maternal adverse events (those suspected of being causally related to treatment were considered adverse drug reactions) leading to cessation of treatment. RESULTS An independent panel evaluated the recorded advers... Mehr ...