Background: The prevalence of respiratory allergy in children is increasing. Epigenetic DNA methylation changes are plausible underlying molecular mechanisms. Results: Saliva samples collected in substudies of two longitudinal birth cohorts in Belgium (FLEHS1 & FLEHS2) were used to discover and confirm DNA methylation signatures that can differentiate individuals with respiratory allergy from healthy subjects. Genome-wide analysis with Illumina Methylation 450K BeadChips revealed 23 differentially methylated gene regions (DMRs) in saliva from 11y old allergic children (N=26) vs. controls (... Mehr ...
| Verfasser: |
Langie, Sabine A S
Moisse, Matthieu
Szarc Vel Szic, Katarzyna
Van Der Plas, Ellen
Koppen, Gudrun
De Prins, Sofie
Louwies, Tijs
Nelen, Vera
Van Camp, Guy
Lambrechts, Diether
Schoeters, Greet
Vanden Berghe, Wim
De Boever, Patrick |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2018 |
| Reihe/Periodikum: |
Langie , S A S , Moisse , M , Szarc Vel Szic , K , Van Der Plas , E , Koppen , G , De Prins , S , Louwies , T , Nelen , V , Van Camp , G , Lambrechts , D , Schoeters , G , Vanden Berghe , W & De Boever , P 2018 , ' GLI2 promoter hypermethylation in saliva of children with a respiratory allergy ' , Clinical Epigenetics , vol. 10 , 50 . https://doi.org/10.1186/s13148-018-0484-1 |
| Schlagwörter: |
DNA methylation
/ GLI2
/ Illumina Methylation 450K BeadChip
/ Respiratory allergy
/ Saliva
/ Promoter Regions
/ Genetic
/ Genome-Wide Association Study
/ Epigenesis
/ Humans
/ Child
/ Preschool
/ Male
/ Zinc Finger Protein Gli2/genetics
/ Saliva/chemistry
/ Case-Control Studies
/ Respiratory Hypersensitivity/genetics
/ Belgium
/ CpG Islands
/ Female
/ Nuclear Proteins/genetics
/ Longitudinal Studies |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-26586721 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://portal.findresearcher.sdu.dk/da/publications/61816462-d946-4cfe-8f61-91bed31cba0b |
