Familial aggregation and antimicrobial response dose-dependently affect the risk for Crohn's disease.
peer reviewed ; BACKGROUND:: An increased risk of Crohn's disease (CD) has been reported consistently in first-degree relatives of patients. Our aim was to test whether a combination of CD-associated genes involved in innate immunity and/or antibody responses to microbial antigens may be valuable in identifying healthy relatives at risk. METHODS:: We investigated 86 families from Belgium and northern France, 45 with at least 3 first-degree relatives with CD, 24 with a single case, and 17 control families without inflammatory bowel disease (IBD). The cohort consisted of 186 CD patients, 290 hea... Mehr ...
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Dokumenttyp: | journal article |
Erscheinungsdatum: | 2010 |
Verlag/Hrsg.: |
Lippincott Williams & Wilkins
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Schlagwörter: | antimicrobial antibodies / disease prediction / familial aggregation / ibd incidence / nod2 / inflammatory-bowel-disease / antineutrophil cytoplasmic antibodies / clinical characteristics / age / anticipation / concordance / prevalence / diagnosis / belgium / couples / Human health sciences / Gastroenterology & hepatology / Sciences de la santé humaine / Gastroentérologie & hépatologie |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-26585350 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://orbi.uliege.be/handle/2268/38482 |