This dataset is part of the manuscript "New insights into the genetic etiology of Alzheimer’s disease and related dementias" by Bellenguez, Küçükali, et al. Nature Genetics 2022. Publication link: https://www.nature.com/articles/s41588-022-01024-z GitHub repository of all QTL/TWAS data shared for this study: https://github.com/SleegersLab-VIBCMN/EADB_GWAS_NatureGenetics_QTL_TWAS For details, please see the publication. For any questions, please contact Fahri Küçükali (fahri.kucukali@uantwerpen.vib.be) and Kristel Sleegers (Kristel.Sleegers@uantwerpen.vib.be). Significant eQTL catalogues are compressed with gzip and tar achieve of expression TWAS reference panels are compressed with bzip2. eQTL catalogues The files show significant eQTL - gene pairs mapped in AMP-AD brain and EADB Belgian LCL cohorts. The catalogues are in hg38/GRCh38 human genome build. Most of the columns in the files are based on FastQTL output (http://fastqtl.sourceforge.net/). eQTL file columns: variant_id - ID of the significant eQTL variant based on the dbSNPv151 rsID annotation or hg38/GRCh38 CHR_POS_REF_ALT ID if rsID not available. gene_id - eGene ENSG gene ID based on GENCODEv24 (AMP-AD) or GENCODEv32 (EADB Belgian) tss_distance - Genomic distance between eQTL variant and eGene ma_samples - Number of samples carrying the minor allele ma_count - Total count of minor alleles maf - Minor allele frequency pval_nominal - Nominal P-value of the association slope - Slope of the association with respect to alternative (ALT) allele indicated on column 14 slope_se - Standard error of the slope pval_nominal_threshold - Nominal P-value significant threshold for this eGene min_pval_nominal - Most significant P-value observed for this eGene pval_beta - permutation P-value obtained via beta approximation and later used to calculate Storey q-values gene_name - eGene name based on GENCODEv24 (AMP-AD) and GENCODEv32 (EADB Belgian) GRCh38_chr_pos - Genomic position of the variant, separated by underscore ref_alt - Reference (REF) and alternative (ALT) ...