Health-related quality of life in acromegalic subjects : data from AcroBel, the Belgian Registry on acromegaly

Objective: To assess the impairment of quality of life (QoL), evaluated by the acromegaly QoL (AcroOoL) questionnaire, in patients with controlled and uncontrolled acromegaly. Design: Cross-sectional evaluation of AcroBel, a national observational registry of acromegalic patients newly diagnosed or in follow-up. Methods: Disease perception by the patients was evaluated by the disease-specific signs and symptoms score (SSS) and QoL was assessed by the AcroOoL questionnaire. Hormonal status was determined by central measurements of GH and IGF-I. Results: Patients (n = 291) had a median GH of 1.4... Mehr ...