Use of chimerism analysis after allogeneic stem cell transplantation: Belgian guidelines and review of the current literature.

BACKGROUND: Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment option in both adult and pediatric patients with malignant and non-malignant hematological diseases. Chimerism analysis, which determines the donor or recipient origin of hematopoietic cells in HSCT recipients, is an essential aspect of post-HSCT follow-up. OBJECTIVES: To review the current literature and develop Belgian consensus guidelines for the use of chimerism analysis in the standard of care after allogeneic HSCT. METHODS: Non-systematic review of the literature in consultancy with the members... Mehr ...