Standardization of somatic variant classifications in solid and haematological tumours by a two-Level approach of biological and clinical classes : an Initiative of the Belgian ComPerMed Expert Panel
In most diagnostic laboratories, targeted next-generation sequencing (NGS) is currently the default assay for the detection of somatic variants in solid as well as haematological tumours. Independent of the method, the final outcome is a list of variants that differ from the human genome reference sequence of which some may relate to the establishment of the tumour in the patient. A critical point towards a uniform patient management is the assignment of the biological contribution of each variant to the malignancy and its subsequent clinical impact in a specific malignancy. These so-called bi... Mehr ...
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Dokumenttyp: | journalarticle |
Erscheinungsdatum: | 2019 |
Schlagwörter: | Medicine and Health Sciences / Cancer Research / Oncology / cancer / classification / guideline / NGS / variant / JOINT-CONSENSUS-RECOMMENDATION / SEQUENCE VARIANTS / GUIDELINES / ASSOCIATION / GENOMICS / COLLEGE |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-26529076 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://biblio.ugent.be/publication/8656040 |