Non-myeloablative allogeneic hematopoietic cell transplantation following fludarabine plus 2 Gy TBI or ATG plus 8 Gy TLI: a phase II randomized study from the Belgian Hematological Society
Background: Few studies thus far have compared head-to-head different non-myelooablative conditioning regimens for allogeneic hematopoietic cell transplantation (allo-HCT). Methods: Here, we report the results of a phase II multicenter randomized study comparing non-myeloablative allo-HCT from HLA-identical siblings (n = 54) or from 10/10 HLA-matched unrelated donors (n = 40) with either fludarabine plus 2 Gy total body irradiation (Flu-TBI arm; n = 49) or 8 Gy TLI + anti-thymocyte globulin (TLI-ATG arm; n = 45) conditioning. Results: The 180-day cumulative incidences of grade II-IV acute GVHD... Mehr ...
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Dokumenttyp: | journalarticle |
Erscheinungsdatum: | 2015 |
Schlagwörter: | Medicine and Health Sciences / ATG / TLI / TBI / Non-myeloablative conditioning / allo-HCT / GVHD / Graft-versus-leukemia effects / VERSUS-HOST-DISEASE / TOTAL LYMPHOID IRRADIATION / LEUKEMIA WORKING PARTY / MYCOPHENOLATE-MOFETIL / MARROW-TRANSPLANTATION / ANTITHYMOCYTE GLOBULIN / MALIGNANT DISEASES / EUROPEAN GROUP / OLDER PATIENTS / RELAPSE RISK |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-26528779 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://biblio.ugent.be/publication/5968509 |