Introduction: Belgium launched a large program (www.integreo.be) to restructure care delivery towards more integrated care. In a first phase, 20 projects have been conceived by loco-regional consortia including health and social care providers with patient representatives. These projects had to plan changes in the care provision through networks (re)structuring at different levels (patient, professionals, and organizations) in geographical areas with a population of around 150,000 people. Projects are now in the phase of selection, to be thereafter implemented. The objective of this communication is to present an analysis of the projects proposals focused on the links between co-creation during conception and future strengthening (or creation) of an appropriate type of loco-regional governance (Tenbensel 2017). Theory – methods: We performed a combination of structured analysis of all the projects submission file, targeted project managers’ interviews and simulation through agent based modelling. The focus was on co-creation during conception and loco-regional governance strengthening. We used the definition of Greenhalgh for co-creation, i.e. aligning priorities and development of all partners via dynamic, locally adaptive community-providers-managers partnerships (Greenhalgh et al. 2016). Concerning governance, we adopt the attributes from Tenbensel, with the idea that there are no ideal form, but a best fit form to a given context (Tenbensel 2017). In the analysis, we tried to identify the three types of mechanisms, as proposed in the Coleman’s diagram (Coleman 1990) through which co-creation could lead to different form of governance. We used an agent based modelling approach to make explicit those possible mechanisms. Results: An initial screening of the proposals shed light on the multiple logics that influenced the proposals content and that may strengthen or hamper further development of loco-regional governance (I.e. power (in)balance; (un)shared vision; sense of ownership; technocratic versus ...