The prothrombin gene G20210A variant in an unselected thromboembolic population. A Belgian prospective clinical study

peer reviewed ; The presence of the 2021 OA allele of the prothrombin gene has recently been shown to be a risk factor of venous thromboembolism, probably mediated through increased prothrombin levels. The aim of the study was to determine the frequency of the prothrombin 2021 OA allele in 193 consecutive unselected patients with venous thromboembolism and 100 healthy controls and to analyze the clinical profile associa!ed wi~h this new inherited thrombophilic factof. In agreement with previous reports, we found a frequency of 7.3% of heterozygous carriers of the 2021 OA allele among patients... Mehr ...