Intra-field heterogeneity of soil properties, such as soil organic carbon (SOC), nitrogen (N), phosphorous (P), exchangeable cations, pH, or soil texture, is a function of complex interactions between biological factors, physical factors, and historic agricultural management. Mapping the crop growth and final yield heterogeneity and quantifying their link with soil properties can contribute to an optimization of amendment/fertilizer application and crop yield in a management variable zones (MVZ) approach. To this end, we studied a field of 17 ha consisting of four former fields that were merged in early 2017 and cropped with winter wheat in 2018. Historical management practices data were collected. The topsoil characteristics were analyzed by grid-based sampling and kriged to create maps. We tested the capacity of a multispectral MicaSense ® RedEdge-M TM camera sensor embedded on an unmanned aerial vehicle (UAV) to map in-season growth of winter wheat. Relating several vegetation indices (VIs) to the plant area index (PAI) measured in the field highlighted the red-edge NDVI (RENDVI) as the most suitable to follow the crop growth throughout the growing season. The georeferenced final grain yield of the winter wheat was measured by a combine harvester. The spatial patterns in RENDVI at three phenological stages were mapped and analyzed together with the yield map. For each of these images a conditional inference forest (CI-forest) algorithm was used to identify the soil properties significantly influencing these spatial patterns. Historical management practices of the four former fields have induced significant heterogeneity in soil properties and crop growth. The spatial patterns of RENDVI are rather constant over time and their Spearman rank correlation with yield is similar along the growing season (r ≃ 0.7). Soil properties explain between 87% (mid-March) to 78% (mid-May) of the variance in RENDVI throughout the growing season, as well as 66% of the variance in yield. The pH and exchangeable K are the most ...