Immunohistochemistry as a screening tool for NTRK gene fusions: results of a first Belgian ring trial
Abstract A Belgian ring trial for pan-TRK immunohistochemistry (IHC) staining was organised to harmonise pan-TRK IHC staining protocols and interpretation. As a reference method, the VENTANA pan-TRK Assay (clone EPR17341) on the Benchmark Ultra platform was selected. Six samples were selected: 2 negative, 2 fusion positive and 2 samples with wild-type endogenous TRK expression. Each participating laboratory stained the slides using their routine pan-TRK IHC and reported their results. In addition, they were asked to return one TRK-stained slide from each case. The coordinating lab evaluated th... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2020 |
Reihe/Periodikum: | Virchows Archiv ; volume 478, issue 2, page 283-291 ; ISSN 0945-6317 1432-2307 |
Verlag/Hrsg.: |
Springer Science and Business Media LLC
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Schlagwörter: | Cell Biology / Molecular Biology / General Medicine / Pathology and Forensic Medicine |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-26507674 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://dx.doi.org/10.1007/s00428-020-02921-6 |