Less veno-occlusive disease after intravenous versus oral busulfan for autologous haematopoietic stem cell transp.l antation: the Belgian paediatric experlence

peer reviewed ; Busulfan is commonly used in preparative conditioning regimens prior to haematopoietic stem cell transplantation in children and young adults for malignant and non-malignant disorders. For many years busulfan was only available in oral form, resulting in large inter- and intra-patients variability in plasma exposure, associated with higher graft failure rate as weil as higher toxicity such as veno-occlusive disease. With the development of an intravenous formulation of busulfan, a more accu rate control of both the inter- and intra-patient variability has been provided. The goa... Mehr ...