Genome-wide linkage scan for loci associated with epilepsy in Belgian shepherd dogs

Abstract Background Idiopathic epilepsy in the Belgian shepherd dog is known to have a substantial genetic component. The objective of this study was to identify genomic regions associated with the expression of generalized seizures in the Belgian Tervuren and Sheepdog. Results DNA from 366 dogs, of which 74 were classified as epileptic, representing two extended families were subjected to a genome-wide linkage scan using 410 microsatellite markers yielding informative coverage averaging 5.95 ± 0.21 Mb. Though previous studies based on pedigree analyses proposed a major gene of influence, the... Mehr ...

Verfasser: Regan Kelly R
Grossman Deborah I
Belanger Janelle M
Oberbauer Anita M
Famula Thomas R
Dokumenttyp: Artikel
Erscheinungsdatum: 2010
Reihe/Periodikum: BMC Genetics, Vol 11, Iss 1, p 35 (2010)
Verlag/Hrsg.: BMC
Schlagwörter: Genetics / QH426-470
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-26501181
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://doi.org/10.1186/1471-2156-11-35