Validation of a Chromosome 14 Risk Haplotype for Idiopathic Epilepsy in the Belgian Shepherd Dog Found to Be Associated with an Insertion in the RAPGEF5 Gene

An idiopathic epilepsy (IE) risk haplotype on canine chromosome (CFA) 14 has been reported to interact with the CFA37 common risk haplotype in the Belgian shepherd (BS). Additional IE cases and control dogs were genotyped for the risk haplotypes to validate these previous findings. In the new cohort, the interaction between the two regions significantly elevated IE risk. When the haplotypes were analyzed individually, particular haplotypes on both CFA14 (ACTG) and 37 (GG) were associated with elevated IE risk, though only the CFA37 AA was significantly associated (p < 0.003) with reduced ri... Mehr ...

Verfasser: Belanger, Janelle M
Heinonen, Tiina
Famula, Thomas R
Mandigers, Paul JJ
Leegwater, Peter A
Hytönen, Marjo K
Lohi, Hannes
Oberbauer, Anita M
Dokumenttyp: Artikel
Erscheinungsdatum: 2022
Reihe/Periodikum: Genes, vol 13, iss 7
Verlag/Hrsg.: eScholarship
University of California
Schlagwörter: Biological Sciences / Genetics / Neurosciences / Brain Disorders / Human Genome / Biotechnology / Rare Diseases / Epilepsy / Neurodegenerative / Aetiology / 2.1 Biological and endogenous factors / Animals / Belgium / Dog Diseases / Dogs / Genetic Predisposition to Disease / Haplotypes / Humans / ras Guanine Nucleotide Exchange Factors / dog / idiopathic epilepsy / RAPGEF5 / risk haplotype
Sprache: unknown
Permalink: https://search.fid-benelux.de/Record/base-26499048
Datenquelle: BASE; Originalkatalog
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Link(s) : https://escholarship.org/uc/item/1dd8q7ft