Transmission of primary resistance mutation K103N in a cluster of Belgian young patients from different risk groups

Background We analysed the distribution of an HIV‐1 subtype B strain resistant to efavirenz and nevirapine among incident infections in the Belgian population. Method The Belgian AIDS reference laboratories searched their databases for HIV‐1 subtype B sequences harbouring the K103N mutation in the reverse transcriptase (RT) or the C67S and V77I mutations in the protease (PR). We included the earliest RT sequence available of drug‐naïve patients as well as sequences related to treatment failure. Fifty sequences were aligned omitting the codon 103 and submitted to phylogenetic analysis. Epidemio... Mehr ...