Genetic polymorphisms of CYP2C9 and CYP2C19 in the Beninese and Belgian populations

Aims To investigate the distribution of cytochrome P450 2C9 ( CYP2C9 ) and 2C19 ( CYP2C19 ) genotype frequencies in the Beninese and Belgian Caucasian populations. Methods Beninese ( n = 111) and Belgian ( n = 121) were genotyped for CYP2C9 * 2 , * 3 , * 4 , * 5 , and * 11 as well as for CYP2C19 * 2 and * 3 . Results The distribution of alleles was: CYP2C9 * 1 : 95.5 vs. 82.2% ( P < 0.001); CYP2C9 * 2 : 0 vs. 10% ( P < 0.001); CYP2C9 * 3 : 0 vs. 7.4% ( P < 0.01); CYP2C9 * 4 : both 0%; CYP2C9 * 5 : 1.8 vs. 0% ( P = 0.05); and CYP2C9 * 11 : 2.7 vs. 0.4% ( P < 0.05). The frequencies o... Mehr ...