Mutations in glucocerebrosidase are a major genetic risk factor for Parkinsons disease and increase susceptibility to dementia in a Flanders-Belgian cohort
Abstract: Objective: To investigate the frequency of glucocerebrosidase (GBA) mutations in a Flanders-Belgian Parkinson's disease (PD) patient cohort and to assess genotype-phenotype correlations. Methods: We performed an in-depth sequencing of all coding exons of GBA in 266 clinically well characterized PD patients and 536 healthy control individuals. Results: We identified rare, heterozygous GBA mutations in 12 PD patients (4.5%) and in 2 healthy control individuals (0.37%), confirming the genetic association of GBA mutations with PD in the Flanders-Belgian population (p < 0.001). The pat... Mehr ...
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Dokumenttyp: | acceptedVersion |
Erscheinungsdatum: | 2016 |
Schlagwörter: | Biology / Human medicine |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-26496074 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://hdl.handle.net/10067/1351010151162165141 |
Abstract: Objective: To investigate the frequency of glucocerebrosidase (GBA) mutations in a Flanders-Belgian Parkinson's disease (PD) patient cohort and to assess genotype-phenotype correlations. Methods: We performed an in-depth sequencing of all coding exons of GBA in 266 clinically well characterized PD patients and 536 healthy control individuals. Results: We identified rare, heterozygous GBA mutations in 12 PD patients (4.5%) and in 2 healthy control individuals (0.37%), confirming the genetic association of GBA mutations with PD in the Flanders-Belgian population (p < 0.001). The patient carriers had a more severe Unified Parkinson's Disease Rating Scale (UPDRS) motor score than non-carriers. Also, GBA mutation status was a significant, independent predictor for the presence of dementia (OR = 12.43, 95% CI: 2.27-68.14. p = 0.004). Genetic association of PD with the common p.E326K and p.T369M variants in GBA was absent. Conclusion: In our Flanders-Belgian cohort, carrier status of a heterozygous GBA mutation was a strong genetic risk factor for PD. The GBA mutation frequency of 4.5% is comparable to previously reported data in other European PD patient cohorts. Furthermore, our clinical data suggest a more severe motor phenotype and a strong predisposition to dementia in GBA mutation carriers. (C) 2016 Elsevier Ireland Ltd. All rights reserved.