1.

Alterations in mgrB or its promoter region in Escherichia coli , Enterobacter spp. and Klebsiella spp.

2.

Alterations in mgrB or its promoter region in Escherichia coli , Enterobacter spp. and Klebsiella spp.

3.

Alterations in mgrB or its promoter region in Escherichia coli , Enterobacter spp. and Klebsiella spp.

4.

Alterations in mgrB or its promoter region in Escherichia coli , Enterobacter spp. and Klebsiella spp.

5.

Alterations in mgrB or its promoter region in Escherichia coli , Enterobacter spp. and Klebsiella spp.

6.

Alterations in mgrB or its promoter region in Escherichia coli , Enterobacter spp. and Klebsiella spp.

7.

Alterations in mgrB or its promoter region in Escherichia coli , Enterobacter spp. and Klebsiella spp.

1.

Single alteration leading to colistin resistance (no other mutations in PmrAB and PhoPQ detected).

2.

Single alteration leading to colistin resistance (no other mutations in PmrAB and PhoPQ detected).

3.

Single alteration leading to colistin resistance (no other mutations in PmrAB and PhoPQ detected).

4.

Single alteration leading to colistin resistance (no other mutations in PmrAB and PhoPQ detected).

5.

Single alteration leading to colistin resistance (no other mutations in PmrAB and PhoPQ detected).

6.

Single alteration leading to colistin resistance (no other mutations in PmrAB and PhoPQ detected).

7.

Single alteration leading to colistin resistance (no other mutations in PmrAB and PhoPQ detected).

1.

Origin and characteristics of clonally related isolates.

2.

Origin and characteristics of clonally related isolates.

3.

Origin and characteristics of clonally related isolates.

4.

Origin and characteristics of clonally related isolates.

5.

Origin and characteristics of clonally related isolates.

6.

Origin and characteristics of clonally related isolates.

7.

Origin and characteristics of clonally related isolates.

1.

Fig 1 -

2.

Fig 1 -

3.

Fig 1 -

4.

Fig 1 -

5.

Fig 1 -

6.

Fig 1 -

7.

Fig 1 -

1.

Sankey diagram of the origin and genetic context of mcr -genes.

2.

Sankey diagram of the origin and genetic context of mcr -genes.

3.

Sankey diagram of the origin and genetic context of mcr -genes.

4.

Sankey diagram of the origin and genetic context of mcr -genes.

5.

Sankey diagram of the origin and genetic context of mcr -genes.

6.

Sankey diagram of the origin and genetic context of mcr -genes.

7.

Sankey diagram of the origin and genetic context of mcr -genes.

1.

Phenotypic antibiotic resistance of colistin-resistant Enterobacterales.

2.

Phenotypic antibiotic resistance of colistin-resistant Enterobacterales.

3.

Phenotypic antibiotic resistance of colistin-resistant Enterobacterales.

4.

Phenotypic antibiotic resistance of colistin-resistant Enterobacterales.

5.

Phenotypic antibiotic resistance of colistin-resistant Enterobacterales.

6.

Phenotypic antibiotic resistance of colistin-resistant Enterobacterales.

7.

Phenotypic antibiotic resistance of colistin-resistant Enterobacterales.

1.

Fig 4 -

2.

Fig 4 -

3.

Fig 4 -

4.

Fig 4 -

5.

Fig 4 -

6.

Fig 4 -

7.

Fig 4 -

1.

Insights into the resistance to critically important antibiotics and the number of virulence classes present in colistin-resistant isolates from different One Health sectors.

2.

Insights into the resistance to critically important antibiotics and the number of virulence classes present in colistin-resistant isolates from different One Health sectors.

3.

Insights into the resistance to critically important antibiotics and the number of virulence classes present in colistin-resistant isolates from different One Health sectors.

4.

Insights into the resistance to critically important antibiotics and the number of virulence classes present in colistin-resistant isolates from different One Health sectors.

5.

Insights into the resistance to critically important antibiotics and the number of virulence classes present in colistin-resistant isolates from different One Health sectors.

6.

Insights into the resistance to critically important antibiotics and the number of virulence classes present in colistin-resistant isolates from different One Health sectors.

7.

Insights into the resistance to critically important antibiotics and the number of virulence classes present in colistin-resistant isolates from different One Health sectors.

1.

Fig 6 -

2.

Fig 6 -

3.

Fig 6 -

4.

Fig 6 -

5.

Fig 6 -

6.

Fig 6 -

7.

Fig 6 -