1.

Colistin use per farm expressed as TiDDDVet.

2.

Colistin use per farm expressed as TiDDDVet.

3.

Colistin use per farm expressed as TiDDDVet.

4.

Colistin use per farm expressed as TiDDDVet.

5.

Colistin use per farm expressed as TiDDDVet.

6.

Colistin use per farm expressed as TiDDDVet.

7.

Colistin use per farm expressed as TiDDDVet.

1.

Sequenced isolates and their phenotypic and genotypic characteristics.

2.

Sequenced isolates and their phenotypic and genotypic characteristics.

3.

Sequenced isolates and their phenotypic and genotypic characteristics.

4.

Sequenced isolates and their phenotypic and genotypic characteristics.

5.

Sequenced isolates and their phenotypic and genotypic characteristics.

6.

Sequenced isolates and their phenotypic and genotypic characteristics.

7.

Sequenced isolates and their phenotypic and genotypic characteristics.

1.

Genomes used as reference for the detection of mutations linked to colistin resistance.

2.

Genomes used as reference for the detection of mutations linked to colistin resistance.

3.

Genomes used as reference for the detection of mutations linked to colistin resistance.

4.

Genomes used as reference for the detection of mutations linked to colistin resistance.

5.

Genomes used as reference for the detection of mutations linked to colistin resistance.

6.

Genomes used as reference for the detection of mutations linked to colistin resistance.

7.

Genomes used as reference for the detection of mutations linked to colistin resistance.

1.

Alterations in mgrB or its promoter region in Escherichia coli , Enterobacter spp. and Klebsiella spp.

2.

Alterations in mgrB or its promoter region in Escherichia coli , Enterobacter spp. and Klebsiella spp.

3.

Alterations in mgrB or its promoter region in Escherichia coli , Enterobacter spp. and Klebsiella spp.

4.

Alterations in mgrB or its promoter region in Escherichia coli , Enterobacter spp. and Klebsiella spp.

5.

Alterations in mgrB or its promoter region in Escherichia coli , Enterobacter spp. and Klebsiella spp.

6.

Alterations in mgrB or its promoter region in Escherichia coli , Enterobacter spp. and Klebsiella spp.

7.

Alterations in mgrB or its promoter region in Escherichia coli , Enterobacter spp. and Klebsiella spp.

1.

Single alteration leading to colistin resistance (no other mutations in PmrAB and PhoPQ detected).

2.

Single alteration leading to colistin resistance (no other mutations in PmrAB and PhoPQ detected).

3.

Single alteration leading to colistin resistance (no other mutations in PmrAB and PhoPQ detected).

4.

Single alteration leading to colistin resistance (no other mutations in PmrAB and PhoPQ detected).

5.

Single alteration leading to colistin resistance (no other mutations in PmrAB and PhoPQ detected).

6.

Single alteration leading to colistin resistance (no other mutations in PmrAB and PhoPQ detected).

7.

Single alteration leading to colistin resistance (no other mutations in PmrAB and PhoPQ detected).

1.

Origin and characteristics of clonally related isolates.

2.

Origin and characteristics of clonally related isolates.

3.

Origin and characteristics of clonally related isolates.

4.

Origin and characteristics of clonally related isolates.

5.

Origin and characteristics of clonally related isolates.

6.

Origin and characteristics of clonally related isolates.

7.

Origin and characteristics of clonally related isolates.

1.

Fig 1 -

2.

Fig 1 -

3.

Fig 1 -

4.

Fig 1 -

5.

Fig 1 -

6.

Fig 1 -

7.

Fig 1 -

1.

Sankey diagram of the origin and genetic context of mcr -genes.

2.

Sankey diagram of the origin and genetic context of mcr -genes.

3.

Sankey diagram of the origin and genetic context of mcr -genes.

4.

Sankey diagram of the origin and genetic context of mcr -genes.

5.

Sankey diagram of the origin and genetic context of mcr -genes.

6.

Sankey diagram of the origin and genetic context of mcr -genes.

7.

Sankey diagram of the origin and genetic context of mcr -genes.

1.

Phenotypic antibiotic resistance of colistin-resistant Enterobacterales.

2.

Phenotypic antibiotic resistance of colistin-resistant Enterobacterales.

3.

Phenotypic antibiotic resistance of colistin-resistant Enterobacterales.

4.

Phenotypic antibiotic resistance of colistin-resistant Enterobacterales.

5.

Phenotypic antibiotic resistance of colistin-resistant Enterobacterales.

6.

Phenotypic antibiotic resistance of colistin-resistant Enterobacterales.

7.

Phenotypic antibiotic resistance of colistin-resistant Enterobacterales.

1.

Fig 4 -

2.

Fig 4 -

3.

Fig 4 -

4.

Fig 4 -

5.

Fig 4 -

6.

Fig 4 -

7.

Fig 4 -