1.

Global view of BLAST comparisons between the mcr -harboring sequences and the most similar reference plasmid sequence (in grey) according to blastn.

2.

Global view of BLAST comparisons between the mcr -harboring sequences and the most similar reference plasmid sequence (in grey) according to blastn.

3.

Global view of BLAST comparisons between the mcr -harboring sequences and the most similar reference plasmid sequence (in grey) according to blastn.

4.

Global view of BLAST comparisons between the mcr -harboring sequences and the most similar reference plasmid sequence (in grey) according to blastn.

5.

Global view of BLAST comparisons between the mcr -harboring sequences and the most similar reference plasmid sequence (in grey) according to blastn.

6.

Global view of BLAST comparisons between the mcr -harboring sequences and the most similar reference plasmid sequence (in grey) according to blastn.

7.

Global view of BLAST comparisons between the mcr -harboring sequences and the most similar reference plasmid sequence (in grey) according to blastn.

1.

Overview of sampling dates, sites sampled per measurement, number of samples collected per measurement and presence of colistin-resistant Enterobacterales.

2.

Overview of sampling dates, sites sampled per measurement, number of samples collected per measurement and presence of colistin-resistant Enterobacterales.

3.

Overview of sampling dates, sites sampled per measurement, number of samples collected per measurement and presence of colistin-resistant Enterobacterales.

4.

Overview of sampling dates, sites sampled per measurement, number of samples collected per measurement and presence of colistin-resistant Enterobacterales.

5.

Overview of sampling dates, sites sampled per measurement, number of samples collected per measurement and presence of colistin-resistant Enterobacterales.

6.

Overview of sampling dates, sites sampled per measurement, number of samples collected per measurement and presence of colistin-resistant Enterobacterales.

7.

Overview of sampling dates, sites sampled per measurement, number of samples collected per measurement and presence of colistin-resistant Enterobacterales.

1.

Colistin use per farm expressed as TiDDDVet.

2.

Colistin use per farm expressed as TiDDDVet.

3.

Colistin use per farm expressed as TiDDDVet.

4.

Colistin use per farm expressed as TiDDDVet.

5.

Colistin use per farm expressed as TiDDDVet.

6.

Colistin use per farm expressed as TiDDDVet.

7.

Colistin use per farm expressed as TiDDDVet.

1.

Sequenced isolates and their phenotypic and genotypic characteristics.

2.

Sequenced isolates and their phenotypic and genotypic characteristics.

3.

Sequenced isolates and their phenotypic and genotypic characteristics.

4.

Sequenced isolates and their phenotypic and genotypic characteristics.

5.

Sequenced isolates and their phenotypic and genotypic characteristics.

6.

Sequenced isolates and their phenotypic and genotypic characteristics.

7.

Sequenced isolates and their phenotypic and genotypic characteristics.

1.

Genomes used as reference for the detection of mutations linked to colistin resistance.

2.

Genomes used as reference for the detection of mutations linked to colistin resistance.

3.

Genomes used as reference for the detection of mutations linked to colistin resistance.

4.

Genomes used as reference for the detection of mutations linked to colistin resistance.

5.

Genomes used as reference for the detection of mutations linked to colistin resistance.

6.

Genomes used as reference for the detection of mutations linked to colistin resistance.

7.

Genomes used as reference for the detection of mutations linked to colistin resistance.

1.

Alterations in mgrB or its promoter region in Escherichia coli , Enterobacter spp. and Klebsiella spp.

2.

Alterations in mgrB or its promoter region in Escherichia coli , Enterobacter spp. and Klebsiella spp.

3.

Alterations in mgrB or its promoter region in Escherichia coli , Enterobacter spp. and Klebsiella spp.

4.

Alterations in mgrB or its promoter region in Escherichia coli , Enterobacter spp. and Klebsiella spp.

5.

Alterations in mgrB or its promoter region in Escherichia coli , Enterobacter spp. and Klebsiella spp.

6.

Alterations in mgrB or its promoter region in Escherichia coli , Enterobacter spp. and Klebsiella spp.

7.

Alterations in mgrB or its promoter region in Escherichia coli , Enterobacter spp. and Klebsiella spp.

1.

Single alteration leading to colistin resistance (no other mutations in PmrAB and PhoPQ detected).

2.

Single alteration leading to colistin resistance (no other mutations in PmrAB and PhoPQ detected).

3.

Single alteration leading to colistin resistance (no other mutations in PmrAB and PhoPQ detected).

4.

Single alteration leading to colistin resistance (no other mutations in PmrAB and PhoPQ detected).

5.

Single alteration leading to colistin resistance (no other mutations in PmrAB and PhoPQ detected).

6.

Single alteration leading to colistin resistance (no other mutations in PmrAB and PhoPQ detected).

7.

Single alteration leading to colistin resistance (no other mutations in PmrAB and PhoPQ detected).

1.

Origin and characteristics of clonally related isolates.

2.

Origin and characteristics of clonally related isolates.

3.

Origin and characteristics of clonally related isolates.

4.

Origin and characteristics of clonally related isolates.

5.

Origin and characteristics of clonally related isolates.

6.

Origin and characteristics of clonally related isolates.

7.

Origin and characteristics of clonally related isolates.

1.

Fig 1 -

2.

Fig 1 -

3.

Fig 1 -

4.

Fig 1 -

5.

Fig 1 -

6.

Fig 1 -

7.

Fig 1 -

1.

Sankey diagram of the origin and genetic context of mcr -genes.

2.

Sankey diagram of the origin and genetic context of mcr -genes.

3.

Sankey diagram of the origin and genetic context of mcr -genes.

4.

Sankey diagram of the origin and genetic context of mcr -genes.

5.

Sankey diagram of the origin and genetic context of mcr -genes.

6.

Sankey diagram of the origin and genetic context of mcr -genes.

7.

Sankey diagram of the origin and genetic context of mcr -genes.