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Objectives of the TROTS registry with respect to primary upper extremity deep venous thrombosis.

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In- and exclusion criteria for the TROTS registry, primary upper extremity deep venous thrombosis specific.

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Overview of the main collected parameters in the TROTS registry.

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MILP model used to generate a schedule for the RT treatment scheduling problem.

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S1 Data -

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Schematic overview of the MILP-based schedule construction and validation phases before implementation.

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Data used as model inputs for the computational experiments of each center.

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Key performance indicators defined by the RT centers.

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Main infeasibilities and limitations found during the schedule construction method and corresponding model adjustments.

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Performance comparison between the schedule built manually and the MILP model in the NKI.