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Metabolomic and lipidomic assessment of the metabolic syndrome in Dutch middle-aged individuals reveals novel biological signatures separating health and disease

Surowiec, Izabella, Noordam, Raymond, Bennett, Kate, Beekman, Marian, Slagboom, P. Eline, Lundstedt, Torbjörn, van Heemst, Diana
Veröffentlicht in: Metabolomics ; volume 15, issue 2 ; ISSN 1573-3882 1573-3890;
2019

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Genetics and Not Shared Environment Explains Familial Resemblance in Adult Metabolomics Data

Pool, Rene, Hagenbeek, Fiona A., Hendriks, Anne M., Van Dongen, Jenny, Willemsen, Gonneke, De Geus, Eco, Consortium, Consortium M., Willems Van Dijk, Ko, Verhoeven, Aswin, Suchiman, H. Eka, Beekman, Marian, Slagboom, P. Eline, Harms, Amy C., Hankemeier, Thomas, Boomsma, Dorret I.
Veröffentlicht in: Pool , R , Hagenbeek , F A , Hendriks , A M , Van Dongen , J , Willemsen , G , De Geus , E , Consortium , C M , Willems Van Dijk , K , Verhoeven , A , Suchiman , H E , Beekman , M , Slagboom , P E , Harms , A C , Hankemeier , T & Boomsma , D I 2020 , ' Genetics and Not Shared Environment Explains Familial Resemblance in Adult Metabolomics Data ' , Twin Research and Human Genetics , vol. 23 , no. 3 , pp. 145-155 . https://doi.org/10.1017/thg.2020.53;
2020

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Meta-analysis on blood transcriptomic studies identifies consistently coexpressed protein-protein interaction modules as robust markers of human aging

van den Akker, Erik B, Passtoors, Willemijn M, Jansen, Rick, van Zwet, Erik W, Goeman, Jelle J, Hulsman, Marc, Emilsson, Valur, Perola, Markus, Willemsen, Gonneke, Penninx, Brenda W J H, Heijmans, Bas T, Maier, Andrea B, Boomsma, Dorret I, Kok, Joost N, Slagboom, Pieternella E, Reinders, Marcel J T, Beekman, Marian
Veröffentlicht in: van den Akker , E B , Passtoors , W M , Jansen , R , van Zwet , E W , Goeman , J J , Hulsman , M , Emilsson , V , Perola , M , Willemsen , G , Penninx , B W J H , Heijmans , B T , Maier , A B , Boomsma , D I , Kok , J N , Slagboom , P E , Reinders , M J T & Beekman , M 2014 , ' Meta-analysis on blood transcriptomic studies identifies consistently coexpressed protein-protein interaction modules as robust markers of human aging ' , Aging Cell , vol. 13 , no. 2 , pp. 216-225 . https://doi.org/10.1111/acel.12160;
2014

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Heritability estimates for 361 blood metabolites across 40 genome-wide association studies

Hagenbeek, Fiona A., Pool, Rene, van Dongen, Jenny, Draisma, Harmen H. M., Jan Hottenga, Jouke, Willemsen, Gonneke, Abdellaoui, Abdel, Fedko, Iryna O., den Braber, Anouk, Visser, Pieter Jelle, de Geus, Eco J. C. N., Willems van Dijk, Ko, Verhoeven, Aswin, Suchiman, H. Eka, Beekman, Marian, Slagboom, P. Eline, van Duijn, Cornelia M., Harms, Amy C., Hankemeier, Thomas, Bartels, Meike, Nivard, Michel G., Boomsma, Dorret I.
Veröffentlicht in: BBMRI Metabolomics Consortium , Hagenbeek , F A , Pool , R , van Dongen , J , Draisma , H H M , Jan Hottenga , J , Willemsen , G , Abdellaoui , A , Fedko , I O , den Braber , A , Visser , P J , de Geus , E J C N , Willems van Dijk , K , Verhoeven , A , Suchiman , H E , Beekman , M , Slagboom , P E , van Duijn , C M , Harms , A C , Hankemeier , T , Bartels , M , Nivard , M G & Boomsma , D I 2020 , ' Heritability estimates for 361 blood metabolites across 40 genome-wide association studies ' , Nature Communications , vol. 11 , no. 1 , 39 . https://doi.org/10.1038/s41467-019-13770-6;
2020

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Blood metabolomic measures associate with present and future glycemic control in type 2 diabetes

't Hart, Leen M., Vogelzangs, Nicole, Mook-Kanamori, Dennis O., Brahimaj, Adela, Nano, Jana, van der Heijden, Amber A.W.A., Willems van Dijk, Ko, Slieker, Roderick C., Steyerberg, Ewout W., Ikram, M. Arfan, Beekman, Marian, Boomsma, Dorret I., van Duijn, Cornelia M., Slagboom, P. Eline, Stehouwer, Coen D.A., Schalkwijk, Casper G., Arts, Ilja C.W., Dekker, Jacqueline M., Dehghan, Abbas, Muka, Taulant, van der Kallen, Carla J.H., Nijpels, Giel, van Greevenbroek, Marleen M.J.
Veröffentlicht in: 't Hart , L M , Vogelzangs , N , Mook-Kanamori , D O , Brahimaj , A , Nano , J , van der Heijden , A A W A , Willems van Dijk , K , Slieker , R C , Steyerberg , E W , Ikram , M A , Beekman , M , Boomsma , D I , van Duijn , C M , Slagboom , P E , Stehouwer , C D A , Schalkwijk , C G , Arts , I C W , Dekker , J M , Dehghan , A , Muka , T , van der Kallen , C J H , Nijpels , G & van Greevenbroek , M M J 2018 , ' Blood metabolomic measures associate with present and future glycemic control in type 2 diabetes ' , Journal of Clinical Endocrinology and Metabolism , vol. 103 , no. 12 , pp. 4569-4579 . https://doi.org/10.1210/jc.2018-01165;
2018

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Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31.

Styrkarsdottir, Unnur, Thorleifsson, Gudmar, Helgadottir, Hafdis T, Bomer, Nils, Metrustry, Sarah, Bierma-Zeinstra, S, Strijbosch, Annelieke M, Evangelou, Evangelos, Hart, Deborah, Beekman, Marian, Jonasdottir, Aslaug, Sigurdsson, Asgeir, Eiriksson, Finnur F, Thorsteinsdottir, Margret, Frigge, Michael L, Kong, Augustine, Gudjonsson, Sigurjon A, Magnusson, Olafur T, Masson, Gisli, Hofman, Albert, Arden, Nigel K, Ingvarsson, Thorvaldur, Lohmander, Stefan, Kloppenburg, Margreet, Rivadeneira, Fernando, Nelissen, Rob G H H, Spector, Tim, Uitterlinden, Andre, Slagboom, P Eline, Thorsteinsdottir, Unnur, Jonsdottir, Ingileif, Valdes, Ana M, Meulenbelt, Ingrid, van Meurs, Joyce, Jonsson, Helgi, Stefansson, Kari
2014

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Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length:the ENGAGE consortium

van der Spek, Ashley, Broer, Linda, Draisma, Harmen H M, Pool, René, Albrecht, Eva, Beekman, Marian, Mangino, Massimo, Raag, Mait, Nyholt, Dale R, Dharuri, Harish K, Codd, Veryan, Amin, Najaf, de Geus, Eco J C, Deelen, Joris, Demirkan, Ayse, Yet, Idil, Fischer, Krista, Haller, Toomas, Henders, Anjali K, Isaacs, Aaron, Medland, Sarah E, Montgomery, Grant W, Mooijaart, Simon P, Strauch, Konstantin, Suchiman, H Eka D, Vaarhorst, Anika A M, van Heemst, Diana, Wang-Sattler, Rui, Whitfield, John B, Willemsen, Gonneke, Wright, Margaret J, Martin, Nicholas G, Samani, Nilesh J, Metspalu, Andres, Eline Slagboom, P, Spector, Tim D, Boomsma, D.I., van Duijn, Cornelia M, Gieger, Christian
Veröffentlicht in: van der Spek , A , Broer , L , Draisma , H H M , Pool , R , Albrecht , E , Beekman , M , Mangino , M , Raag , M , Nyholt , D R , Dharuri , H K , Codd , V , Amin , N , de Geus , E J C , Deelen , J , Demirkan , A , Yet , I , Fischer , K , Haller , T , Henders , A K , Isaacs , A , Medland , S E , Montgomery , G W , Mooijaart , S P , Strauch , K , Suchiman , H E D , Vaarhorst , A A M , van Heemst , D , Wang-Sattler , R , Whitfield , J B , Willemsen , G , Wright , M J , Martin , N G , Samani , N J , Metspalu , A , Eline Slagboom , P , Spector , T D , Boomsma , D I , van Duijn , C M & Gieger , C 2019 , ' Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length : the ENGAGE consortium ' , Scientific Reports , vol. 9 , no. 1 , 11623 , pp. 11623 . https://doi.org/10.1038/s41598-019-47282-6;
2019

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Metabolite ratios as potential biomarkers for type 2 diabetes:a DIRECT study

Molnos, Sophie, Wahl, Simone, Haid, Mark, Eekhoff, E Marelise W, Pool, René, Floegel, Anna, Deelen, Joris, Much, Daniela, Prehn, Cornelia, Breier, Michaela, Draisma, Harmen H, van Leeuwen, Nienke, Simonis-Bik, Annemarie M C, Jonsson, Anna, Willemsen, Gonneke, Bernigau, Wolfgang, Wang-Sattler, Rui, Suhre, Karsten, Peters, Annette, Thorand, Barbara, Herder, Christian, Rathmann, Wolfgang, Roden, Michael, Gieger, Christian, Kramer, Mark H H, van Heemst, Diana, Pedersen, Helle K, Gudmundsdottir, Valborg, Schulze, Matthias B, Pischon, Tobias, de Geus, Eco J C, Boeing, Heiner, Boomsma, Dorret I, Ziegler, Anette G, Slagboom, P. Eline, Hummel, Sandra, Beekman, Marian, Grallert, Harald, Brunak, Søren, McCarthy, Mark I, Gupta, Ramneek, Pearson, Ewan R, Adamski, Jerzy, 't Hart, Leen M
Veröffentlicht in: Molnos , S , Wahl , S , Haid , M , Eekhoff , E M W , Pool , R , Floegel , A , Deelen , J , Much , D , Prehn , C , Breier , M , Draisma , H H , van Leeuwen , N , Simonis-Bik , A M C , Jonsson , A , Willemsen , G , Bernigau , W , Wang-Sattler , R , Suhre , K , Peters , A , Thorand , B , Herder , C , Rathmann , W , Roden , M , Gieger , C , Kramer , M H H , van Heemst , D , Pedersen , H K , Gudmundsdottir , V , Schulze , M B , Pischon , T , de Geus , E J C , Boeing , H , Boomsma , D I , Ziegler , A G , Slagboom , P E , Hummel , S , Beekman , M , Grallert , H , Brunak , S , McCarthy , M I , Gupta , R , Pearson , E R , Adamski , J & 't Hart , L M 2018 , ' Metabolite ratios as potential biomarkers for type 2 diabetes : a DIRECT study ' , Diabetologia , vol. 61 , no. 1 , pp. 117-129 . https://doi.org/10.1007/s00125-017-4436-7;
2018

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WGS-based telomere length analysis in Dutch family trios implicates stronger maternal inheritance and a role for RRM1 gene

Nersisyan, Lilit, Nikoghosyan, Maria, Francioli, Laurent C., Menelaou, Androniki, Pulit, Sara L., Elbers, Clara C., Kloosterman, Wigard P., van Setten, Jessica, Nijman, Isaäc J., Renkens, Ivo, de Bakker, Paul I. W., van Dijk, Freerk, Neerincx, Pieter B. T., Deelen, Patrick, Kanterakis, Alexandros, Dijkstra, Martijn, Byelas, Heorhiy, van der Velde, K. Joeri, Platteel, Mathieu, Swertz, Morris A., Wijmenga, Cisca, Palamara, Pier Francesco, Pe’er, Itsik, Ye, Kai, Lameijer, Eric-Wubbo, Moed, Matthijs H., Beekman, Marian, de Craen, Anton J. M., Suchiman, H. Eka D., Slagboom, P. Eline, Guryev, Victor, Abdellaoui, Abdel, Jan Hottenga, Jouke, Kattenberg, Mathijs, Willemsen, Gonneke, Boomsma, Dorret I., van Leeuwen, Elisabeth M., Karssen, Lennart C., Amin, Najaf, Rivadeneira, Fernando, Isaacs, Aaron, Hofman, Albert, Uitterlinden, André G., van Duijn, Cornelia M., van Oven, Mannis, Kayser, Manfred, Vermaat, Martijn, Laros, Jeroen F. J., den Dunnen, Johan T.
Veröffentlicht in: Scientific Reports ; volume 9, issue 1 ; ISSN 2045-2322;
2019

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The Genome of the Netherlands: design, and project goals

Boomsma, Dorret I, Wijmenga, Cisca, Slagboom, Eline P, Swertz, Morris A, Karssen, Lennart C, Abdellaoui, Abdel, Ye, Kai, Guryev, Victor, Vermaat, Martijn, van Dijk, Freerk, Francioli, Laurent C, Hottenga, Jouke Jan, Laros, Jeroen F J, Li, Qibin, Li, Yingrui, Cao, Hongzhi, Chen, Ruoyan, Du, Yuanping, Li, Ning, Cao, Sujie, van Setten, Jessica, Menelaou, Androniki, Pulit, Sara L, Hehir-Kwa, Jayne Y, Beekman, Marian, Elbers, Clara C, Byelas, Heorhiy, de Craen, Anton J M, Deelen, Patrick, Dijkstra, Martijn, den Dunnen, Johan T, de Knijff, Peter, Houwing-Duistermaat, Jeanine, Koval, Vyacheslav, Estrada, Karol, Hofman, Albert, Kanterakis, Alexandros, Enckevort, David van, Mai, Hailiang, Kattenberg, Mathijs, van Leeuwen, Elisabeth M, Neerincx, Pieter B T, Oostra, Ben, Rivadeneira, Fernanodo, Suchiman, Eka H D, Uitterlinden, Andre G, Willemsen, Gonneke, Wolffenbuttel, Bruce H, Wang, Jun, de Bakker, Paul I W
Veröffentlicht in: European Journal of Human Genetics ; volume 22, issue 2, page 221-227 ; ISSN 1018-4813 1476-5438;
2013