1.

Fig 6 -

2.

Fig 6 -

3.

Fig 6 -

4.

Fig 6 -

5.

Fig 6 -

6.

Fig 6 -

7.

Fig 6 -

8.

Fig 6 -

1.

Additional file 1 of Clinical and molecular epidemiological features of critically ill patients with invasive group A Streptococcus infections: a Belgian multicenter case-series

2.

Additional file 1 of Clinical and molecular epidemiological features of critically ill patients with invasive group A Streptococcus infections: a Belgian multicenter case-series

3.

Additional file 1 of Clinical and molecular epidemiological features of critically ill patients with invasive group A Streptococcus infections: a Belgian multicenter case-series

4.

Additional file 1 of Clinical and molecular epidemiological features of critically ill patients with invasive group A Streptococcus infections: a Belgian multicenter case-series

1.

Distribution of the number of colistin-resistant Enterobacterales species by One Health sector and country.

2.

Distribution of the number of colistin-resistant Enterobacterales species by One Health sector and country.

3.

Distribution of the number of colistin-resistant Enterobacterales species by One Health sector and country.

4.

Distribution of the number of colistin-resistant Enterobacterales species by One Health sector and country.

5.

Distribution of the number of colistin-resistant Enterobacterales species by One Health sector and country.

6.

Distribution of the number of colistin-resistant Enterobacterales species by One Health sector and country.

7.

Distribution of the number of colistin-resistant Enterobacterales species by One Health sector and country.

8.

Distribution of the number of colistin-resistant Enterobacterales species by One Health sector and country.

1.

S2 Fig -

2.

S2 Fig -

3.

S2 Fig -

4.

S2 Fig -

5.

S2 Fig -

6.

S2 Fig -

7.

S2 Fig -

8.

S2 Fig -

1.

Global view of BLAST comparisons between the mcr -harboring sequences and the most similar reference plasmid sequence (in grey) according to blastn.

2.

Global view of BLAST comparisons between the mcr -harboring sequences and the most similar reference plasmid sequence (in grey) according to blastn.

3.

Global view of BLAST comparisons between the mcr -harboring sequences and the most similar reference plasmid sequence (in grey) according to blastn.

4.

Global view of BLAST comparisons between the mcr -harboring sequences and the most similar reference plasmid sequence (in grey) according to blastn.

5.

Global view of BLAST comparisons between the mcr -harboring sequences and the most similar reference plasmid sequence (in grey) according to blastn.

6.

Global view of BLAST comparisons between the mcr -harboring sequences and the most similar reference plasmid sequence (in grey) according to blastn.

7.

Global view of BLAST comparisons between the mcr -harboring sequences and the most similar reference plasmid sequence (in grey) according to blastn.

8.

Global view of BLAST comparisons between the mcr -harboring sequences and the most similar reference plasmid sequence (in grey) according to blastn.

1.

Virulence potential of ColR-E from different One Health sectors in Belgium and the Netherlands.

2.

Virulence potential of ColR-E from different One Health sectors in Belgium and the Netherlands.

3.

Virulence potential of ColR-E from different One Health sectors in Belgium and the Netherlands.

4.

Virulence potential of ColR-E from different One Health sectors in Belgium and the Netherlands.

5.

Virulence potential of ColR-E from different One Health sectors in Belgium and the Netherlands.

6.

Virulence potential of ColR-E from different One Health sectors in Belgium and the Netherlands.

7.

Virulence potential of ColR-E from different One Health sectors in Belgium and the Netherlands.

8.

Virulence potential of ColR-E from different One Health sectors in Belgium and the Netherlands.

9.

Virulence potential of ColR-E from different One Health sectors in Belgium and the Netherlands.

1.

Overview of sampling dates, sites sampled per measurement, number of samples collected per measurement and presence of colistin-resistant Enterobacterales.

2.

Overview of sampling dates, sites sampled per measurement, number of samples collected per measurement and presence of colistin-resistant Enterobacterales.

3.

Overview of sampling dates, sites sampled per measurement, number of samples collected per measurement and presence of colistin-resistant Enterobacterales.

4.

Overview of sampling dates, sites sampled per measurement, number of samples collected per measurement and presence of colistin-resistant Enterobacterales.

5.

Overview of sampling dates, sites sampled per measurement, number of samples collected per measurement and presence of colistin-resistant Enterobacterales.

6.

Overview of sampling dates, sites sampled per measurement, number of samples collected per measurement and presence of colistin-resistant Enterobacterales.

7.

Overview of sampling dates, sites sampled per measurement, number of samples collected per measurement and presence of colistin-resistant Enterobacterales.

8.

Overview of sampling dates, sites sampled per measurement, number of samples collected per measurement and presence of colistin-resistant Enterobacterales.

1.

Colistin use per farm expressed as TiDDDVet.

2.

Colistin use per farm expressed as TiDDDVet.

3.

Colistin use per farm expressed as TiDDDVet.

4.

Colistin use per farm expressed as TiDDDVet.

5.

Colistin use per farm expressed as TiDDDVet.

6.

Colistin use per farm expressed as TiDDDVet.

7.

Colistin use per farm expressed as TiDDDVet.

8.

Colistin use per farm expressed as TiDDDVet.

1.

Sequenced isolates and their phenotypic and genotypic characteristics.

2.

Sequenced isolates and their phenotypic and genotypic characteristics.

3.

Sequenced isolates and their phenotypic and genotypic characteristics.

4.

Sequenced isolates and their phenotypic and genotypic characteristics.

5.

Sequenced isolates and their phenotypic and genotypic characteristics.

6.

Sequenced isolates and their phenotypic and genotypic characteristics.

7.

Sequenced isolates and their phenotypic and genotypic characteristics.

8.

Sequenced isolates and their phenotypic and genotypic characteristics.

1.

Genomes used as reference for the detection of mutations linked to colistin resistance.

2.

Genomes used as reference for the detection of mutations linked to colistin resistance.

3.

Genomes used as reference for the detection of mutations linked to colistin resistance.

4.

Genomes used as reference for the detection of mutations linked to colistin resistance.

5.

Genomes used as reference for the detection of mutations linked to colistin resistance.

6.

Genomes used as reference for the detection of mutations linked to colistin resistance.

7.

Genomes used as reference for the detection of mutations linked to colistin resistance.

8.

Genomes used as reference for the detection of mutations linked to colistin resistance.

1.

Alterations in mgrB or its promoter region in Escherichia coli , Enterobacter spp. and Klebsiella spp.

2.

Alterations in mgrB or its promoter region in Escherichia coli , Enterobacter spp. and Klebsiella spp.

3.

Alterations in mgrB or its promoter region in Escherichia coli , Enterobacter spp. and Klebsiella spp.

4.

Alterations in mgrB or its promoter region in Escherichia coli , Enterobacter spp. and Klebsiella spp.

5.

Alterations in mgrB or its promoter region in Escherichia coli , Enterobacter spp. and Klebsiella spp.

6.

Alterations in mgrB or its promoter region in Escherichia coli , Enterobacter spp. and Klebsiella spp.

7.

Alterations in mgrB or its promoter region in Escherichia coli , Enterobacter spp. and Klebsiella spp.

8.

Alterations in mgrB or its promoter region in Escherichia coli , Enterobacter spp. and Klebsiella spp.

1.

Single alteration leading to colistin resistance (no other mutations in PmrAB and PhoPQ detected).

2.

Single alteration leading to colistin resistance (no other mutations in PmrAB and PhoPQ detected).

3.

Single alteration leading to colistin resistance (no other mutations in PmrAB and PhoPQ detected).

4.

Single alteration leading to colistin resistance (no other mutations in PmrAB and PhoPQ detected).

5.

Single alteration leading to colistin resistance (no other mutations in PmrAB and PhoPQ detected).

6.

Single alteration leading to colistin resistance (no other mutations in PmrAB and PhoPQ detected).

7.

Single alteration leading to colistin resistance (no other mutations in PmrAB and PhoPQ detected).

8.

Single alteration leading to colistin resistance (no other mutations in PmrAB and PhoPQ detected).

1.

Origin and characteristics of clonally related isolates.

2.

Origin and characteristics of clonally related isolates.

3.

Origin and characteristics of clonally related isolates.

4.

Origin and characteristics of clonally related isolates.

5.

Origin and characteristics of clonally related isolates.

6.

Origin and characteristics of clonally related isolates.

7.

Origin and characteristics of clonally related isolates.

8.

Origin and characteristics of clonally related isolates.

1.

Fig 1 -

2.

Fig 1 -

3.

Fig 1 -

4.

Fig 1 -

5.

Fig 1 -

6.

Fig 1 -

7.

Fig 1 -

8.

Fig 1 -

1.

Sankey diagram of the origin and genetic context of mcr -genes.

2.

Sankey diagram of the origin and genetic context of mcr -genes.

3.

Sankey diagram of the origin and genetic context of mcr -genes.

4.

Sankey diagram of the origin and genetic context of mcr -genes.

5.

Sankey diagram of the origin and genetic context of mcr -genes.

6.

Sankey diagram of the origin and genetic context of mcr -genes.

7.

Sankey diagram of the origin and genetic context of mcr -genes.

8.

Sankey diagram of the origin and genetic context of mcr -genes.

1.

Phenotypic antibiotic resistance of colistin-resistant Enterobacterales.

2.

Phenotypic antibiotic resistance of colistin-resistant Enterobacterales.

3.

Phenotypic antibiotic resistance of colistin-resistant Enterobacterales.

4.

Phenotypic antibiotic resistance of colistin-resistant Enterobacterales.

5.

Phenotypic antibiotic resistance of colistin-resistant Enterobacterales.

6.

Phenotypic antibiotic resistance of colistin-resistant Enterobacterales.

7.

Phenotypic antibiotic resistance of colistin-resistant Enterobacterales.

8.

Phenotypic antibiotic resistance of colistin-resistant Enterobacterales.

1.

Fig 4 -

2.

Fig 4 -

3.

Fig 4 -

4.

Fig 4 -

5.

Fig 4 -

6.

Fig 4 -

7.

Fig 4 -

8.

Fig 4 -

1.

Insights into the resistance to critically important antibiotics and the number of virulence classes present in colistin-resistant isolates from different One Health sectors.

2.

Insights into the resistance to critically important antibiotics and the number of virulence classes present in colistin-resistant isolates from different One Health sectors.

3.

Insights into the resistance to critically important antibiotics and the number of virulence classes present in colistin-resistant isolates from different One Health sectors.

4.

Insights into the resistance to critically important antibiotics and the number of virulence classes present in colistin-resistant isolates from different One Health sectors.

5.

Insights into the resistance to critically important antibiotics and the number of virulence classes present in colistin-resistant isolates from different One Health sectors.

6.

Insights into the resistance to critically important antibiotics and the number of virulence classes present in colistin-resistant isolates from different One Health sectors.

7.

Insights into the resistance to critically important antibiotics and the number of virulence classes present in colistin-resistant isolates from different One Health sectors.

8.

Insights into the resistance to critically important antibiotics and the number of virulence classes present in colistin-resistant isolates from different One Health sectors.

1.

Comparison of colistin resistance between Belgium and the Netherlands by measurement and by sector.

2.

Comparison of colistin resistance between Belgium and the Netherlands by measurement and by sector.

3.

Comparison of colistin resistance between Belgium and the Netherlands by measurement and by sector.

4.

Comparison of colistin resistance between Belgium and the Netherlands by measurement and by sector.

5.

Comparison of colistin resistance between Belgium and the Netherlands by measurement and by sector.

6.

Comparison of colistin resistance between Belgium and the Netherlands by measurement and by sector.

7.

Comparison of colistin resistance between Belgium and the Netherlands by measurement and by sector.

8.

Comparison of colistin resistance between Belgium and the Netherlands by measurement and by sector.

9.

Comparison of colistin resistance between Belgium and the Netherlands by measurement and by sector.

1.

Association of colistin resistance with prior colistin use in pig farms in Belgium (n = 14) and the Netherlands (n = 15).

2.

Association of colistin resistance with prior colistin use in pig farms in Belgium (n = 14) and the Netherlands (n = 15).

3.

Association of colistin resistance with prior colistin use in pig farms in Belgium (n = 14) and the Netherlands (n = 15).

4.

Association of colistin resistance with prior colistin use in pig farms in Belgium (n = 14) and the Netherlands (n = 15).

5.

Association of colistin resistance with prior colistin use in pig farms in Belgium (n = 14) and the Netherlands (n = 15).

6.

Association of colistin resistance with prior colistin use in pig farms in Belgium (n = 14) and the Netherlands (n = 15).

7.

Association of colistin resistance with prior colistin use in pig farms in Belgium (n = 14) and the Netherlands (n = 15).

8.

Association of colistin resistance with prior colistin use in pig farms in Belgium (n = 14) and the Netherlands (n = 15).

9.

Association of colistin resistance with prior colistin use in pig farms in Belgium (n = 14) and the Netherlands (n = 15).