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Schematic overview of the histopathological examination process of a punch biopsy specimen suspicious for basal cell carcinoma.
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Fig 1 -
Clinicopathological characteristics of all included patients.
Clinicopathological characteristics of patients with a more aggressive subtype in additional step sections (levels 5–8) vs. the remaining patients.
Overview of HE levels of the 14 patients with a more aggressive BCC component in deeper HE slides (levels 5–8).
General overview of switching replications design.
Fig 2 -
Fig 3 -
Explanation of the design principles from the Van Rijt et al. [56] study, adopted in the current study.