Increased synovial lipodystrophy induced by high fat diet aggravates synovitis in experimental osteoarthritis

obesity has been pointed out as the main contributing factor for the association between OA and MetS, in studies showing a markedly attenuated association after adjustment for body mass index [14]. [...]animals in both the HFD and OA-HFD groups had a significant decrease in weight gain, which was probably related to the increase in systemic inflammation induced by the diet [28]. [...]hyperlipidemia could drive M1 macrophage polarization in the OA synovium, resulting in a major presence of proinflammatory cytokines, as has been described in adipose tissue [52, 53]. In the OA group we also found... Mehr ...