Resistin upregulates chemokine production by fibroblast-like synoviocytes from patients with rheumatoid arthritis

study is needed to show the function of the three putative receptors against resistin stimulation on FLSs. Chemokines upregulated by resistin stimulation in the present study were mostly ELR+ C-X-C motif chemokines. [...]resistin may be involved in angiogenesis and inflammatory cell accumulation, in the synovial tissue in RA via ELR+ C-X-C motif chemokine production. CXCL8 is strongly expressed in the synovial tissue of patients with RA with a high level of disease activity [24]. [...]CXCL8 may be involved in angiogenesis, inflammatory cell migration, and osteoclast differentiation in synovial... Mehr ...