New clues to the nature of immunoglobulin G4-related disease: a retrospective Japanese multicenter study of baseline clinical features of 334 cases

The CDC consist of three parts including clinical features showing characteristic diffuse/localized swelling or masses in single or multiple organs, elevation of serum IgG4 concentrations (?135 mg/dl), and histopathological findings including marked lymphoplasmacytic infiltration, fibrosis, and infiltration of IgG4-positive cells (IgG4+/IgG+?>?40% and?>?10 IgG4+ plasma cells/HPF). Since the cutoff number of IgG4-positive plasma cells of the CDC is lower than those of the Consensus statement on the pathology of IgG4-RD [16], we made the diagnosis of IgG4-RD referring to the Consensus stat... Mehr ...