Platelets are activated in ANCA-associated vasculitis via thrombin-PARs pathway and can activate the alternative complement pathway

According to the previous study, 1 mM Gly-Pro-Arg-Pro (GPRP, Sigma-Aldrich, St. Louis, MO, USA) was added to prevent fibrin polymerization [35]. [ Table Omitted - see PDF ] Table 1 General data of the 31 AAV patients in active stage Parameters Value General clinical data No. subjects 31 Gender (M/F) 19/12 Age 59.4?±?13.2 ANCA target antigen (MPO/PR3) 29/3 Initial Scr (?mol/L) 448.6?±?250.6 Urinary protein (g/24 hr) 0.76 (00.5-2.01) BVAS 18.3?±?5.7 Renal involvement 21 (91.3%) Pulmonary involvement 21 (91.3%) ENT involvement 6 (26.1%) Nervous system involvement 5 (21.7%) Pathologic data No. sub... Mehr ...