Serum connective tissue growth factor is a highly discriminatory biomarker for the diagnosis of rheumatoid arthritis

the combination of ACPA and RF has limited performance benefits over either individual index [6, 7]. [...]the search for new serum biomarkers, especially those with high specificity and sensitivity to improve the current diagnostic tests for RA, retains great significance. 3 to aggravate bone destruction [12]. [...]Fujishiro et al. found that inhibiting CTGF by neutralizing the anti-CTGF monoclonal antibody (mAb) significantly ameliorated arthritis in a murine model of RA [13]. Furthermore, approximately 30% of patients with RA who have clinical manifestations of the disease may have negative... Mehr ...