Failure to achieve lupus low disease activity state (LLDAS) six months after diagnosis is associated with early damage accrual in Caucasian patients with systemic lupus erythematosus

Wilhem et al. observed that the median time to achieve durable remission, classified in four subtypes according to the principle proposed by the DORIS group, ranged between 1.8 and 11.0 years [10]. [...]increasing-fluctuating anti-dsDNA level rather than absolute values can predict disease flares [34]. [...]in order to enhance the association between minimal acceptable disease activity and long-term outcomes, it would be conceivable to consider rising levels of anti-dsDNA antibodies rather than their steady positivity in the LLDAS definition. [...]the retrospective design of the study prevente... Mehr ...