New insights on the MMP-13 regulatory network in the pathogenesis of early osteoarthritis

and modulating integrin-mediated signaling [44]. [...]MMP-13 is a well-known key player in the pathology of early OA due to its capacity to directly or indirectly initiate the degradation of a wide range of downstream matrix and collagen components via its regulatory factors through specific signaling pathways (Fig. 1). [...]current studies report opposite variation tendencies between autophagy and MMP-13 levels in OA models as well as in autophagy-regulated models, which implies that autophagy may play a protective role in the pathogenesis of OA by inhibiting MMP-13 production. [...]to improv... Mehr ...