Predictive biological markers of systemic lupus erythematosus flares: a systematic literature review

Because of a better understanding of SLE pathogenesis, an increasing number of biomarkers have emerged. Close relationships of serum, plasma or urinary profiles with the course of the disease have been explored. Since the 1970s, no investigators have succeeded in identifying a biomarker with the potential to predict efficiently the occurrence of new flares, despite great clinical necessity. The results can also vary according to the class of Ig considered for the measurement of anti-dsDNA ab (positive results with IgG and negative results with IgM) [16], which could explain, in part, the discr... Mehr ...