Biological function integrated prediction of severe radiographic progression in rheumatoid arthritis: a nested case control study

According to a report by van Steenbergen et al., prediction accuracy of severe radiographic progression reached only 62% using a model consisting of 17 known genetic loci from several replication studies and meta-analysis and clinical factors [4]. [...]we sought to develop a more accurate and reliable prediction model for radiographic progression using a comprehensive approach consisting of GWAS, post-GWAS analysis, and bioinformatics. [...]we collected 4666 miRNA regions from miRbase [13] and their target genes from miRTarBase [14]. [...]we assessed cis and trans-expression quantitative trait... Mehr ...