Enhanced IFN-Alpha production is associated with increased TLR7 retention in the lysosomes of palasmacytoid dendritic cells in systemic lupus erythematosus

Nat Immunol. 2010;11:373-84.Google Scholar Lövgren T, Eloranta ML, Båve U, Alm GV, Rönnblom L. Induction of interferon-? production in plasmacytoid dendritic cells by immune complexes containing nucleic acid released by necrotic or late apoptotic cells and lupus IgG. Dysfunctional interferon-? production by peripheral plasmacytoid dendritic cells upon Toll-like receptor-9 stimulation in patients with systemic lupus erythematosus. Hydroxychloroquine is associated with impaired interferon-alpha and tumor necrosis factor-alpha production by plasmacytoid dendritic cells in systemic lupus erythemat... Mehr ...