Behcets disease risk association fine-mapped on the IL23R-IL12RB2 intergenic region in Koreans

Since two landmark genome-wide association studies (GWAS) performed on Japanese and Turkish populations [2, 3] identified HLA-A, IL10, and IL23R-IL12RB2 to be novel BD susceptibility loci, the association of IL10 and IL23R-IL12RB2 with BD has been replicated thereafter in various ethnic groups including the Chinese Han, Iranian, and Western Algerian populations [4-9]. STAT4 is a transcription factor that transduces IL-12, IL-23, and type 1 interferon signals in T cells and monocytes [12]. [...]the functional relevance of STAT4 in BD appears sensible because T helper (Th) 1 and Th17 cytokines a... Mehr ...