Soluble CD40L is associated with increased oxidative burst and neutrophil extracellular trap release in Behcets disease

phosphorylation of the NF-?B p65 subunit was constitutively increased in neutrophils and monocytes from patients with BD, suggesting chronic baseline activation (Fig. 6f) of these cells. Remarkably, aBD plasma exerted a stronger stimulus on NET release than iBD or HC plasma, correlating with the higher levels of sCD40L in aBD vs iBD. [...]the recapitulation of the stimulating effect of BD plasma on phagocyte function by treatment with rh-sCD40L and the inhibition by sCD40L blockade further support our interpretation that sCD40L carried in BD plasma is directly associated with some of the funct... Mehr ...