Severe intestinal dysbiosis is prevalent in primary Sjogrens syndrome and is associated with systemic disease activity

Because the GI epithelium is affected in pSS, through the inflammation of the exocrine glands as well as through diminished secretions, there are decreased levels of both protective and proliferative factors [6, 13, 14]. [...]the integrity of the epithelium and its barrier function may be compromised in pSS patients, possibly resulting in a perturbed microbiota-host immune system interaction. Results presented as median (interquartile range) or percentage of subjects DMARD disease-modifying anti-rheumatic drug, ESSDAI EULAR Sjögren’s Syndrome Disease Activity Index, ESSPRI EULAR Sjögren’s Synd... Mehr ...