Inhibition of T cell-mediated inflammation in uveitis by a novel anti-CD3 antibody

Background A novel anti-mouse CD3Epsilon antibody, Dow2, recognizes mouse CD3Epsilon without activating T cells and suppresses T-cell activation. The purpose of this study was to determine whether Dow2 can inhibit T cells in uveitis. Methods Experimental autoimmune uveitis (EAU) was induced in mice by immunization with retinal peptides, followed by administration of Dow2. Inflammation was evaluated by color fundus photography, optical coherence tomography, fluorescein angiography, and histology. Intraocular cells from EAU mice were used to examine the effect of Dow2 on retinal antigen-specific... Mehr ...