MRI-detected osteitis is not associated with the presence or level of ACPA alone, but with the combined presence of ACPA and RF

In rheumatoid arthritis (RA) bone marrow edema (BME, osteitis) and anti-citrullinated protein antibodies (ACPA) are associated with radiographic progression. ACPA have been associated with BME, but it is unknown if this association is confined to ACPA and BME. We performed cross-sectional analysis of the association of ACPA, rheumatoid factor (RF) and anti-carbamylated protein (anti-CarP) antibodies with BME and other types of inflammation (synovitis, tenosynovitis) detected by magnetic resonance imaging (MRI). Disease-modifying antirheumatic drug (DMARD)-naïve patients with early arthritis (n... Mehr ...