Inflammation-driven bone formation in a mouse model of ankylosing spondylitis: sequential not parallel processes

Ankylosing spondylitis (AS) is an immune-mediated arthritis particularly targeting the spine and pelvis and is characterised by inflammation, osteoproliferation and frequently ankylosis. Current treatments that predominately target inflammatory pathways have disappointing efficacy in slowing disease progression. Thus, a better understanding of the causal association and pathological progression from inflammation to bone formation, particularly whether inflammation directly initiates osteoproliferation, is required. The proteoglycan-induced spondylitis (PGISp) mouse model of AS was used to hist... Mehr ...