Physiological evidence for diversification of IFNα- and IFNβ-mediated response programs in different autoimmune diseases

Activation of the type I interferon (IFN) response program is described for several autoimmune diseases, including systemic lupus erythematosus (SLE), multiple sclerosis (MS), myositis (IIM) and rheumatoid arthritis (RA). While IFNα contributes to SLE pathology, IFNβ therapy is often beneficial in MS, implying different immunoregulatory roles for these IFNs. This study was aimed to investigate potential diversification of IFNα-and IFNβ-mediated response programs in autoimmune diseases. Peripheral blood gene expression of 23 prototypical type I IFN response genes (IRGs) was determined in 54 hea... Mehr ...