Non-invasive in vivo imaging of arthritis in a collagen-induced murine model with phosphatidylserine-binding near-infrared (NIR) dye

Development of non-invasive molecular imaging techniques that are based on cellular changes in inflammation has been of active interest for arthritis diagnosis. This technology will allow real-time detection of tissue damage and facilitate earlier treatment of the disease, thus, an improvement over X-ray that detects bone damage at the advanced stage. Tracing apoptosis, an event occurring in inflammation, has been a strategy. PSVue®794 is a low-molecular-weight, NIR emitting complex of bis(zinc(2+)dipicolylamine) (Zn-DPA) that binds to phosphatidylserine (PS), a plasma membrane anionic phospho... Mehr ...