IL-17 sequestration via salivary gland gene therapy in a mouse model of Sjogren?s syndrome suppresses disease-associated expression of the putative autoantigen Klk1b22

IL-17 has a putative role in the pathophysiology of Sjogren?s syndrome (SS) and has been shown to be upregulated in the salivary glands of affected individuals. Sequestration of IL-17 with Adenoviral-mediated gene therapy has previously shown a benefit upon the SS-like phenotype in the Aec1/Aec2 mouse model. We sought to understand the proteomic consequences of IL-17 sequestration in the salivary gland of this mouse model as a means of illuminating the role of IL-17 in SS-like disease. Ultrasound-assisted gene transfer (UAGT) was utilized to express a fusion protein composed of the extracellul... Mehr ...