Activating enhancer binding protein 2 epsilon (AP-2ε)-deficient mice exhibit increased matrix metalloproteinase 13 expression and progressive osteoarthritis development

The transcription factor activating enhancer binding protein 2 epsilon (AP-2ε) was recently shown to be expressed during chondrogenesis as well as in articular chondrocytes of humans and mice. Furthermore, expression of AP-2ε was found to be upregulated in affected cartilage of patients with osteoarthritis (OA). Despite these findings, adult mice deficient for AP-2ε (Tfap2e(-/-)) do not exhibit an obviously abnormal cartilaginous phenotype. We therefore analyzed embryogenesis of Tfap2e(-/-) mice to elucidate potential transient abnormalities that provide information on the influence of AP-2ε o... Mehr ...

Verfasser: Niebler, Stephan
Dokumenttyp: Artikel
Reihe/Periodikum: Arthritis research & therapy
Verlag/Hrsg.: London, BioMed Central
Sprache: Englisch
ISSN: 1478-6354
Weitere Identifikatoren: doi: 10.1186/s13075-015-0648-8
Permalink: https://search.fid-benelux.de/Record/olc-benelux-1961017040
URL: NULL
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Datenquelle: Online Contents Benelux; Originalkatalog
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Link(s) : http://dx.doi.org/10.1186/s13075-015-0648-8
http://dx.doi.org/10.1186/s13075-015-0648-8
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