Characterising deviation from treat-to-target strategies for early rheumatoid arthritis: the first three years

Treat-to-target (T2T) strategies using a protocol of pre-defined adjustments of disease-modifying anti-rheumatic drugs (DMARDs) according to disease activity improve outcomes for patients with rheumatoid arthritis (RA). However, successful implementation may be limited by deviations from the protocol. The aim of this study was to determine the prevalence of protocol deviation, explore the reasons and identify subsets of patients in whom treatment protocols are more difficult to follow. In this retrospective cohort study, treatment-naïve patients with RA of less than one year's duration, attend... Mehr ...