An investigation of the added value of an ACPA multiplex assay in an early rheumatoid arthritis setting

Recently, arrays have become available that allow the simultaneous analysis of several anti-citrullinated protein antibody (ACPA) reactivities using distinct citrullinated peptides. Such assays are designed for exploratory studies. The interpretation of positive antibody reactivities can best be made if the diagnostic and prognostic value of a multiplex array in an early arthritis setting is known and if the multiplex-positive patients who are negative according to three commonly used commercial ACPA assays are characterized. Using Thermo Scientific's ImmunoCap ISAC (Immuno Solid-phase Allerge... Mehr ...